Leica Microscope Magnifier M125 B User Manual

Living up to Life  
User Manual  
Leica M125 B  
Leica M165 C B  
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Function of the Microscopes  
The Leica M125 B and Leica M165 C B micro-  
scopes, for which this User Manual has been  
written, are designed for routine examinations  
of cell and tissue cultures, liquids, and sedi-  
ments. This includes examining specimens  
taken from the human body for the purpose  
of gaining information about physiological or  
pathological conditions or inborn anomalies, or  
testing for safety and compatibility for poten-  
tial recipients, or for monitoring therapeutic  
measures.  
other purposes than those for which they are  
intended or not using them within the speci-  
fications of Leica Microsystems CMS GmbH.  
In such cases, the Declaration of Conformity  
shall be invalid.  
instruments in accordance with EN 60601-1. If a  
microscope is electrically connected to a medi-  
cal instrument in accordance with 60601-1, the  
requirements listed in EN 60601-1-1 shall apply.  
Not suitable for examining potentially infec-  
tious specimens. This type of instrument may  
be operated by trained laboratory personnel  
only.  
These (IVD) instruments are not  
intended for use in the patient environ-  
ment defined by DIN VDE 0100-710. Nor are  
they designed to be combined with medical  
IVD  
The above-named microscopes comply with  
the Council Directive 98/79/EC concerning in  
vitro diagnostics.  
Leica M125 B nameplate  
Leica M165 C B nameplate  
The manufacturer assumes no liabil-  
ity for damage caused by, or any  
risks arising from, using the microscope for  
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General Notes  
Use in clean rooms  
The Leica M series can be used in clean rooms  
without any problems.  
The cleaning of glass surfaces and objec-  
tives in particular should be carried out  
exclusively as outlined in the brochure  
"Cleaning of Microscope Optics". The infor-  
mation can be downloaded at:  
Servicing  
Repairs may only be carried out by Leica  
Microsystems-trained service technicians.  
Only original Leica Microsystems spare  
parts may be used.  
Cleaning  
Do not use any unsuitable cleaning agents,  
chemicals or techniques for cleaning.  
ucts/  
. Select your product and go to the "Down-  
load" page.  
Responsibilities of person in charge of  
instrument  
Never use chemicals to clean colored  
surfaces or accessories with rubberized  
parts. This could damage the surfaces,  
and products could be contaminated by  
abraded particles.  
Ensure that the Leica stereomicroscope  
is operated, maintained and repaired by  
authorized and trained personnel only.  
For additional information, refer to page  
56.  
In most cases, we can provide special solu-  
tions on request. Some products can be  
modified, and we can offer other accesso-  
ries for use in clean rooms.  
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4
Important Safety Notes  
User Manual  
Before installing, operating or using the instru-  
ments, read the user manuals listed above. In  
particular, please follow all safety instructions.  
We guarantee the quality of our products.  
Our guarantee covers all faults in materials  
and manufacture. It does not, however, cover  
damage resulting from careless or improper  
handling.  
This User Manual describes the special func-  
tions of the individual modules of the Leica M  
stereomicroscopy series and contains impor-  
tant instructions for their operational safety,  
maintenance, and accessories.  
To maintain the unit in its original condition  
and to ensure safe operation, the user must  
follow the instructions and warnings contained  
in these user manuals.  
You can combine individual system articles  
with articles from external suppliers (e.g. cold  
light sources, etc.). Please read the User Manual  
and the safety instructions from the supplier.  
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Symbols Used  
Warning! Safety hazard!  
Danger due to hot surface.  
This symbol warns against touching hot  
surfaces, e.g. those of light bulbs.  
Disposal  
Notes on how to dispose on the micro-  
This symbol indicates especially impor-  
tant information that is mandatory to  
scope, its components and expend-  
read and observe.  
ables.  
Failure to comply can cause the following:  
Important information  
Hazards to personnel  
Functional disturbances or damaged  
instruments  
This symbol indicates additional infor-  
mation or explanations that are intended  
to provide clarity.  
China RoHS 50 year EFUP (Environ-  
mentally friendly use period)  
IVD labeling  
nstrument for in vitro diagnostics.  
Warning of hazardous electrical voltage  
This symbol indicates especially impor-  
tant information that is mandatory to  
read and observe.  
Explanatory notes  
This symbol within the text stands for addi-  
tional information and explanations.  
IVD  
I
IVD manufacturing date,  
for example 11 / 2011 for  
November 2011.  
Failure to comply can cause the following:  
Figures  
MM/YYYY  
Hazards to personnel  
Functional disturbances or damaged  
instruments  
(1) Numbers in parentheses within the  
descriptions relate to the figures and the  
items within those figures.  
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6
Safety Instructions  
Description  
and mechanical parts unless expressly  
instructed to do so in the instructions.  
Place of use  
The individual modules fulfill the highest  
requirements for observation and docu-  
mentation of Leica stereomicroscopes of  
the M series.  
Only use the instruments in closed, dust  
free rooms and between +10 °C and  
+40 °C. Protect the devices from oil, chemi-  
cals and extreme humidity. If using the  
devices outdoors, protect them from dust  
and moisture. Never use electrical devices  
outdoors.  
The instruments and accessories described in  
this User Manual have been tested for safety and  
potential hazards. The responsible Leica affiliate  
must be consulted whenever the instrument is  
altered, modified or used in conjunction with  
non-Leica components that are outside of the  
scope of this manual!  
Intended use of instrument  
Leica Microsystems microscopes are opti-  
cal instruments for improving the visibility  
of objects or specimens through magnifi-  
cation. Accessories such as optical acces-  
sories, stands, illumination, cameras etc.  
supplement the equipment configuration.  
Electrical components must be placed at  
least 10 cm away from the wall and away  
from flammable substances.  
Unauthorized alterations to the instrument or  
noncompliant use shall void all rights to any  
warranty claims as well as product liability and  
the Declaration of Conformity.  
Avoid large temperature fluctuations,  
direct sunlight and vibrations. These condi-  
tions can distort micrographic images, for  
example.  
Non-intended use  
Using the instrument in any way contrary  
to the specifications in the User Manual can  
lead to bodily harm and damage to objects.  
Never use microscopes for in vivo examina-  
tions or eye surgery if they are not expressly  
intended for such use. Never install any  
other plug or unscrew optical systems  
In warm and warm-damp climatic zones,  
the individual components require special  
care in order to prevent the build-up of  
fungus.  
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Safety Instructions (continued)  
Responsibilities of person in charge of  
instrument  
Before opening the instruments, switch off  
the power and unplug the power cable.  
Integration in third-party products  
When installing Leica products into third-  
party products, the manufacturer of the  
complete system or its dealer is responsible  
for following all applicable safety instruc-  
tions, laws and guidelines.  
These Safety Instructions must be available  
at the workplace.  
Avoid contact with powered electrical  
circuits, which can lead to injury.  
Ensure that:  
The  
M
series stereomicroscopes and  
accessories are operated, maintained and  
repaired by authorized and trained person-  
nel only.  
Transport  
Use the original packaging for shipping or  
Disposal  
transporting the individual modules of the  
Leica M stereomicroscopy series and the  
accessory components.  
Once the product has reached the end of its  
service life, please contact Leica Service or  
Sales about disposal.  
All operators have read, understood and  
observe this User Manual, and particularly  
the safety regulations.  
In order to prevent damage from vibrations,  
disassemble all moving parts that (accord-  
ing to the user manual) can be assembled  
and disassembled by the customer and  
pack them separately.  
Please observe and comply with the  
national and federal laws and regulations  
that are equivalent to EC directives such as  
WEEE.  
Repairs, service work  
Repairs may only be carried out by Leica  
Microsystems-trained service technicians.  
Like all electronic devices, the micro-  
scope, its accessory components and  
Only original Leica Microsystems spare  
parts may be used.  
consumables must never be disposed of with  
general household waste.  
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Safety Instructions (continued)  
Legal regulations  
assignments and work flow (changing tasks  
frequently). Thorough training of the person-  
nel, giving consideration to ergonomic and  
organizational aspects.  
The ergonomic design and construction of the  
Leica M stereomicroscopy series are intended to  
reduce the exertion of the user to a minimum.  
Careful handling  
Observe the generally applicable statu-  
tory and country-specific regulations for  
accident prevention and environmental  
protection.  
Exercise particular care when setting up  
the instruments. If it is specified that two or  
more people are required for setup, compli-  
ance with this is mandatory.  
Never spill any liquids on electrical instru-  
ments. This could cause the stereomicro-  
scope and other equipment to become  
electrically live and damage people and  
instruments.  
EC Declaration of Conformity  
Electrically operated accessories are  
constructed based on the state of the art  
of technology and are provided with an EC  
Declaration of Conformity. See page 55  
Direct contact with eyepieces can be a potential  
transmission path for bacterial and viral infec-  
tions of the eye.  
The risk can be kept to a minimum by using  
personal eyepieces for each individual or  
detachable eyecups.  
Never clean instruments using corro-  
sive cleaning agents or those containing  
acetone. For detailed information about  
care, refer to the User Manual for the instru-  
ment.  
Health risks  
Workplaces with stereomicroscopes facilitate  
and improve the viewing task, but they also  
impose high demands on the eyes and holding  
muscles of the user. Depending on the dura-  
tion of uninterrupted work, asthenopia and  
musculoskeletal problems may occur. For this  
reason, appropriate measures for reduction of  
the workload must be taken:  
Check the power cables regularly. Defective  
power cables can cause injuries.  
Wait for bulbs to cool off before changing  
them. Touching hot bulbs can cause burns.  
Optimal arrangement of workplace, work  
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Safety Instructions (continued)  
Light sources: safety regulations  
External power supply for the focusing  
column  
(Leica M165 C B)  
Permitted power supply:  
SINPRO SPU46-110  
External power supply for TL5000 Ergo  
Permitted power supply:  
SINPRO SPU130-110  
Light sources pose a potential risk from  
glare. Therefore, lamps have to be operated  
in closed housings and in installed condi-  
tion.  
Specifications:  
Input:  
100-240 V AC  
47-63 Hz  
3.2 A  
Never look directly into the beam path  
(blinding hazard).  
Specifications:  
Input:  
100-240 V AC  
47-63 Hz  
1.2 A  
Output: 33 V DC  
3.93 A  
max. 130 W  
For indoor use only.  
Do not select a white, strongly reflective  
background for the specimen.  
Output: 33 V DC  
1.51 A  
For indoor use only.  
Use only the power supply specified  
above. Other power supplies must not  
be used. If the original power supply fails or  
is damaged, it must be replaced. Repair is not  
permitted. Original power supplies are avail-  
able from your Leica branch office or Leica  
dealer.  
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User Manual  
Leica M series  
10  
Contents  
Copyright  
Function of the Microscopes  
General Notes  
Important Safety Notes  
Symbols Used  
Safety Instructions  
2
3
4
5
6
7
Quick Start Guide  
The Fastest Route to Success  
Overview of an M Series Microscope  
The correct interpupillary distance  
Using the Eyepieces  
29  
30  
31  
32  
33  
34  
35  
36  
37  
38  
Focusing  
Adjusting the Resistance of the Focus Drive  
Changing the Magnification (Zoom)  
Click Stops and Magnifications  
Parfocality: More Comfort and Convenience for Your Work  
Iris Diaphragm  
The Leica M Series  
Congratulations!  
A Step Towards Infinity  
The Electronics: Comfort, Convenience and Safety for your Experiments  
16  
14  
15  
Maximum Compatibility  
On We Go  
17  
18  
Eyepieces  
Magnification Factor of the Eyepieces  
Health Notes  
Dioptric Correction  
Dioptric Correction and Parfocality  
Graticules  
40  
41  
42  
43  
44  
Assembly  
Base and Focusing Column  
Optics carrier  
Tube  
Eyepieces  
20  
21  
22  
23  
24  
25  
26  
27  
Objectives  
and  
Objective  
TL5000 Ergo transmitted light base  
Wiring: Connections (Leica M165 C B)  
Cables: Cable Duct  
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11  
Optical Accessories  
The Different Types of Objectives  
46  
Bases  
Leica TL5000 Ergo Transmitted Light Base: Controls  
Leica TL5000 Ergo Transmitted Light Base: Operation  
48  
49  
Technical Data  
Leica TL5000 Ergo Transmitted Light Base  
52  
Appendix  
Calculating the Total Magnification and Field of View Diameter  
Care, Maintenance, Contact Persons  
54  
55  
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The Leica M Series  
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Congratulations!  
Congratulations on obtaining your new Leica M series stereomicroscope.  
We are convinced it will exceed your expectations, as never before have  
we applied our decades of experience in the areas of optics, mechanical  
engineering and ergonomics in such an uncompromising manner.  
Though the reliability and robustness of Leica stereomicroscopes is  
legendary, like any high-tech product, the Leica M series requires a certain  
degree of care and attention. Therefore, we recommend that you read  
this manual. It contains all the information you need regarding operation,  
safety and maintenance. Simply observing a few guidelines will ensure  
that even after years of intensive use, your stereomicroscope will continue  
to work as smoothly and reliably as on the very first day.  
The Leica M series embodies all the qualities you associate with the name  
Leica Microsystems: excellent objectives, high-quality engineering, and  
reliability. Furthermore, the modular design ensures that the M series  
adapts perfectly to your needs—no matter which accessories you require  
for your tasks.  
We wish you the best of success in your work— after all, you are now  
equipped with the best tool!  
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14  
A Step Towards Infinity  
Ever since their introduction by Horatio S. Gree-  
nough, stereomicroscopes have worked accord-  
ing to the optical principles based primarily  
on Ernst Abbe's research. For over a century,  
ingenious optics designers and engineers have  
worked to push magnification, resolution and  
image fidelity to the limit permitted by optics.  
In doing so, they have always been constrained  
by the interrelation between three factors: the  
higher a microscope's resolution, the lower the  
available working distance. If one increases the  
distance of the optical axes, the three-dimen-  
sional image seen by the observer becomes  
distorted— a sphere becomes an ellipse, a flat  
surface curves towards the observer.  
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The Electronics: Comfort, Convenience and Safety for your Experiments  
Never before have electronics been used as  
extensively in a Leica series as in the new M  
series lineup. Optics carrier, tripod, base and  
illuminator are all connected using electrical  
contacts—which provides a number of advan-  
tages.  
Fewer cables  
A large part of the cables have been routed in  
the interior of the column. Data are also trans-  
ferred via the interface between the column,  
the optics carrier and the carrier. The direct  
result is that you need fewer cables—this not  
only makes your workstation neater and more  
comfortable, it even makes it appear larger.  
Contacts not only transmit data, but also supply  
the power.  
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Maximum Compatibility  
Leica engineers were careful to ensure that the  
new Leica M series—like its predecessors—  
remains compatible with existing series. This  
means that objectives, bases, tubes and so on  
can be reused.  
Tubes  
The interface between the optics carrier and  
the tube has remained the same, so exist-  
ing tubes fit the new M series. The new tubes  
are designed for eyepieces with field number  
23, while the predecessor models were only  
designed for field number 21, resulting in a  
smaller object field.  
Objectives  
All new objectives of the Leica M series are  
parfocal.  
Eyepieces  
If you prefer, you can continue to use the previ-  
ous Leica objective series. In this case, parfocal-  
ity is no longer guaranteed.  
The new M series eyepieces have an audible  
and tangible click to provide immediate feed-  
back in case of accidental adjustment.  
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17  
On We Go  
If your new Leica microscope has already  
been assembled and commissioned by your  
Leica consultant, click here to skip through  
the installation instructions and go directly  
to the Quick Start Guide on page 28.  
If, on the other hand, you are assembling the  
microscope yourself, continue with the "Assem-  
bly" chapter, which begins on page 19.  
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Assembly  
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19  
 
Base and Focusing Column  
The first step is to connect the focusing column  
of the M series to the corresponding base.  
Assembling the column adapter  
1. Securely install the column adapter on the  
column using the four included screws.  
Assembling the focusing drive  
2. Securely screw the focusing column to the  
base using the six included screws.  
Tools used  
Allen key, 3 mm  
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Optics carrier  
Tools used  
Assembling the Optics Carrier  
1. Place the optics carrier on the focus-  
ing column so that the screw fits into the  
thread provided and the lug fits into the  
groove.  
Allen key, 4 mm  
2. Press the optics carrier backwards to the  
focusing column and screw it in place using  
your other hand.  
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Tube  
All intermediate tubes that fit between the  
optics carrier and the binocular tube are fitted  
in the same manner.  
Assembling the tube  
2. Push the tube (for example, the inclined  
binocular tube) into the dovetail ring and  
rotate it slightly in both directions until the  
positioning screw meshes with the guide  
groove.  
3. While holding the tube only slightly, care-  
fully tighten the positioning screw. It is  
automatically brought to the correct posi-  
tion.  
Tools used  
No tools required.  
Preparations  
1. Unscrew the positioning screw and remove  
the protective cover.  
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Eyepieces  
Tools used  
Preparation  
Inserting the eyepieces  
No tools required.  
1. If you want to use an optional graticule,  
insert it now (page 44).  
3. Push the eyepieces into the tubes as far as  
they will go and check to ensure that they  
fit tightly and accurately.  
Magnification range  
You can extend the overall magnification range  
using available 10×, 16×, 25× and 40× wide-  
field eyepieces for persons wearing glasses.  
2. Remove the plastic tube guard.  
4. Securely tighten the clamping screws.  
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Objective  
Tools used  
Attaching the objective  
Hold the objective firmly during assem-  
bly and disassembly so that it does not  
fall onto the stage plate. This applies particu-  
larly to the 2x planapochromatic objective,  
which is very heavy. Remove all specimens from  
the stage plate first.  
No tools required.  
Preparation  
1. Remove the protective cap on the optics  
carrier by turning it.  
2. Screw the objective clockwise into the  
optics carrier.  
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TL5000 Ergo transmitted light base  
Unpacking the base  
Focusing drive and column  
1. Unscrew the extension plate from the base  
using the Allen key provided.  
2. Attach your focusing drive column to the  
bottom using the 4 Allen screws.  
The base is delivered with the adapter plate  
installed. Make sure the instruments are  
unpacked on a flat, sufficiently dimensioned,  
and non-slip surface.  
3. Reattach the adapter plate to its original  
position using the 6 Allen screws.  
Refer also to the separately provided  
User Manual for the TL5000 Ergo trans-  
mitted light base.  
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Wiring: Connections (Leica M165 C B)  
The new Leica M series features extensive  
encoding with which various microscope data  
and settings can be read out and reproduced  
later.  
The terminals  
The connection to other instruments is made  
using the terminals on the rear side of the  
column:  
1. 2×CTL2 terminals for auxiliary equipment  
such as the ring illuminator, the base and  
other accessories from the Leica product  
range.  
1
The interface to the optics carrier is on the  
column.  
2
2. Terminal for the 50-watt power supply  
provided.  
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Cables: Cable Duct  
The integrated cable duct in the column  
enables a neat cable layout around the micro-  
scope. For example, the USB or FireWire cables  
of the camera can be stowed in the cable duct.  
Feeding the cables  
1. Unscrew the three screws on the cable  
duct.  
3. Place the cables in the cable duct and screw  
the cover on tightly.  
2. Remove the cover of the cable duct.  
Tip: Estimate the length of the cable ends you  
will need before screwing on the cover.  
For thick cables, it is difficult to change the  
length retroactively.  
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Quick Start Guide  
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28  
 
The Fastest Route to Success  
Your Leica stereomicroscope has been delivered in completely assembled  
condition by your Leica partner, and naturally you want to get right to  
work. Therefore, your next step should be to study the Quick Start Guide,  
which outlines the most important steps at a glance.  
This manual will then familiarize you with the finer details of your micro-  
scope. The following pages contain important, practical information that  
makes using it every day easier.  
Take time to read it – it's worth it!  
The M series Quick Start Guide (included with instrument).  
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29  
Overview of an M Series Microscope  
10  
11  
1
2
3
4
5
6
7
8
9
Switch click stops on/off  
Magnification changer (zoom)  
Coarse/fine focusing  
Transmitted light base  
Interchangeable objective  
Built-in iris diaphragm  
Fastening screw for the binocular tube (or accessories)  
Adjustable eyepiece tubes  
9
8
7
6
1
2
3
Fastening screws for the eyepieces  
10 Eyepieces for spectacle wearers with dioptric correction  
and eyecups  
11 Trinocular tube  
5
4
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30  
The correct interpupillary distance  
The interpupillary distance is correctly set if you  
see a single circular image field when looking  
at a specimen.  
Adjusting the interpupillary distance  
1. Look into the eyepieces.  
3. Slowly approach the eyepieces with your  
eyes until you can see the complete image  
field without corner cutting.  
2. Hold the eyepieces with both hands. Push  
the eyepieces together or separate them  
until you see a circular image.  
If you are still a novice microscope user, you  
may need a short time to become accustomed  
to this. Not to worry—after a little while, it will  
become automatic.  
Reference values  
The distance between eye and eyepiece  
measures approx. 22 mm for 10/23B widefield  
eyepieces for persons wearing glasses.  
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Using the Eyepieces  
The eyepieces form the connection between  
the tube and the eye of the observer. Simply  
push them into the tube and they are ready to  
use.  
If you do not wear glasses:  
1. Hold the eyepiece firmly and rotate the  
eyecups forwards counterclockwise.  
If you wear glasses:  
1. Hold the eyepiece firmly and rotate the  
eyecups counterclockwise towards the rear,  
as otherwise the viewing distance is too  
great.  
2. If an eyepiece is equipped with the inte-  
Each eyepiece offers a certain magnification  
factor that has a determinative effect on the  
total magnification. Furthermore, all Leica  
eyepieces can be equipped with practical grati-  
cules that enable measuring and quantifying of  
specimens.  
Dioptric Correction  
A built-in dioptric correction is available for  
eyeglass wearers. For more information, refer to  
grated dioptric correction, turn the value to  
the "0" mark.  
2. If an eyepiece is equipped with the inte-  
grated dioptric correction, turn the value to  
the "0" mark.  
By the way, one benefit of viewing with  
eyeglasses is  
a
drastically lower risk of  
bacterial transmission (see page 41).  
The soft material of the eyecup also ensures  
that your glasses will not be scratched, even if  
they contact the eyepiece.  
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Leica M series  
32  
Focusing  
Focusing raises or lowers the stereomicroscope  
using the focusing drive. The specimen detail is  
brought into sharp focus as soon as it is in the  
focal point of the objective.  
Focusing  
Coarse/fine adjustment  
The sharpness is adjusted using the coarse/fine  
adjustment.  
The inner, coarse adjustment is used for  
covering great distances.  
The outer, fine adjustment is used for fine  
focusing.  
2. The coarse/fine adjustment carries a  
load of up to 15 kg.  
The focusing drive can be operated either  
left- or right-handed.  
The resolution of the coarse/fine adjust-  
ment is 1 µm.  
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Leica M series  
33  
Adjusting the Resistance of the Focus Drive  
Adjusting the resistance  
Is the focusing drive too loose or too tight?  
Does the equipment tend to slide downwards?  
The resistance can be adjusted individually  
depending on the equipment weight and  
personal preferences as follows:  
1. Grip the outer drive knobs with both hands  
and turn them towards each other until the  
desired resistance is reached during focus-  
ing.  
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Leica M series  
34  
Changing the Magnification (Zoom)  
All M series microscopes have an integrated  
zoom. The name indicates the zoom range  
covered:  
Zooming  
1. Look into the eyepieces.  
2. Focus on the specimen.  
Leica M125 B = 12.5:1  
Leica M165 C B = 16.5:1  
3. Rotate the magnification changer until the  
desired magnification is configured.  
The rotary knob for the zoom can be used either  
left or right-handed.  
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Leica M series  
35  
Click Stops and Magnifications  
The zoom button can optionally be operated  
either with or without ratchet steps. Continu-  
ous zoom is possible when the click stops are  
disabled, which many users find convenient.  
On the other hand, when the click stops are  
enabled, photographs, measurement results  
etc. can be reproduced more accurately.  
Enabling and disabling click stops  
1. Push the top button downwards to disable  
the ratchet steps.  
Magnifications and fields of view  
The formula on page 54 provides additional  
information about the magnifications and field  
of view diameters, with consideration given to  
the position of the magnification changer and  
the eyepiece and objective combination used.  
2. Push the bottom button upwards to enable  
the ratchet steps.  
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User Manual  
Leica M series  
36  
Parfocality: More Comfort and Convenience for Your Work  
All Leica stereomicroscopes are parfocally  
matched, meaning that you can view a focused  
specimen from the lowest to the highest  
magnification without having to refocus. The  
focus needs to be readjusted only if you want  
to view a specimen detail that is located higher  
or lower.  
Parfocality  
1. Enlarge the view to the maximum level.  
2. Focus on the specimen.  
You are done! Even if you select a smaller work-  
ing distance, the specimen remains pin-sharp.  
Requirements for parfocal work  
The parfocality is maintained until you focus on  
another level of the specimen.  
If you are using an eyepiece with dioptric  
correction, the procedure differs from this  
description. For more information, refer to  
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Leica M series  
37  
Iris Diaphragm  
The iris diaphragm in the optics carrier of your  
M series microscope has the same purpose as  
those in a camera shutter: it regulates the avail-  
able light, which changes the depth of field. The  
"depth of field" (or "depth of focus") is the area  
of a specimen that is brought into sharp focus.  
Closing the iris diaphragm  
Opening the Iris Diaphragm  
Close the iris diaphragm by turning the  
knob to the left. The subject appears darker  
and the depth of field increases.  
Open the iris diaphragm by turning the  
knob to the right. The subject now appears  
brighter, but the depth of field decreases.  
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Leica M series  
38  
Eyepieces  
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Leica M series  
39  
Magnification Factor of the Eyepieces  
An eyepiece not only makes it possible to look passively into the micro-  
scope, but also has a critical effect on the maximum magnification. The  
magnification factor is between 10x and 40x.  
The following eyepieces are available for the M series:  
Magnification  
Dioptric Correction  
5 diopter settings  
5 diopter settings  
5 diopter settings  
5 diopter settings  
Order number  
10 450 023  
10 450 024  
10 450 025  
10 450 026  
10×  
16×  
25×  
40×  
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Leica M series  
User Manual  
40  
Health Notes  
Potential sources of infection  
Direct contact with eyepieces is  
a
potential transmission method for  
bacterial and viral infections of the eye. The risk  
can be kept to a minimum by using individual  
eyepieces or detachable eyecups. Eyecups can  
be ordered separately. Please contact your  
Leica partner.  
Separate eyecups are an effective way of prevent-  
ing infections.  
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Leica M series  
41  
 
Dioptric Correction  
All Leica eyepieces are also available with built-  
in dioptric correction, allowing the microscope  
to be used without glasses even by those with  
Using the Dioptric Correction  
1. Set the dioptric correction of both  
eyepieces to the mid position ("0" diopter  
settings).  
Note that when using dioptric correction,  
the advantage of parfocality is lost - thus  
you have to manually refocus each time you  
change the zoom level. To also use parfocality  
with dioptric correction, refer to the instruc-  
tions on page 43  
vision problems. The correction comprises  
diopter settings.  
5
2. While wearing your glasses, look through  
the eyepieces and focus on the specimen.  
3. Rotate both eyepieces to the maximum  
value of "+5".  
4. Hold one eye closed and rotate the other  
eyepiece in the "-" direction until the speci-  
men appears sharp.  
5. Then, open the other eye and correct the  
diopter settings until the image is uniformly  
sharp.  
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User Manual  
Leica M series  
42  
 
Dioptric Correction and Parfocality  
Leica stereomicroscopes are parfocally  
matched. The prerequisite for this is the correct  
setting of the diopters and the parfocality. The  
following adjustments have to be carried out  
only once by each user.  
Adjusting  
7. Look into the eyepieces.  
1. Set the dioptric correction for both  
eyepieces to "0".  
8. Slowly rotate each eyepiece individually  
in the "–" direction until each eye sees the  
object sharply imaged.  
2. Select the lowest magnification and focus  
on a flat specimen.  
9. Select the highest magnification and refo-  
cus if necessary.  
Preparations  
3. Select the highest magnification and read-  
just the sharpness.  
Move the lever of the video/phototube to  
the "observation" position and open the  
diaphragm.  
Now, if you adjust the magnification from the  
lowest to the highest level, the specimen is  
always brought into sharp focus. If not, repeat  
the process.  
4. Select the lowest magnification again, but  
do not look into the eyepieces.  
6. Rotate the eyepieces counterclockwise in  
the "+" direction as far as they will go (+5  
diopter settings).  
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Leica M series  
43  
 
Graticules  
Use  
2. Clamp the graticule on the insert, applying  
moderate pressure. Ensure that the grati-  
cule fits tightly.  
4. You can now align the graticule by rotating  
the eyepiece in the tube and then tighten-  
ing it using the clamping screw.  
Leica graticules make counting easier, particu-  
larly for workstations that are not equipped  
with a digital camera.  
The Leica graticules for length measurements  
and numbering are fitted in mounts and are  
inserted into the eyepieces.  
1. Screw the insert off of the eyepiece.  
3. Screw the insert and graticule firmly into  
place and replace the eyepiece in the tube.  
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User Manual  
Leica M series  
44  
 
Objectives and  
Optical Accessories  
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Leica M series  
45  
The Different Types of Objectives  
To meet the various requirements regarding  
imaging properties, there is a choice of high-  
quality interchangeable planachromatic and  
planapochromatic objectives and also lower-  
priced interchangeable achromatic objectives.  
Achromatic objectives  
Achromatic objectives with a long focal  
length  
For special applications, achromatic objectives  
with long working distances and focal lengths  
of f=100 mm to 400 mm are available.  
The 0.32×, 0.5×, 0.63×, 0.8×, 1×, 1.5×, 2×  
achromatic objectives offer countless variants  
for selecting the object field diameter, magnifi-  
cation ranges and working distances (see page  
54).  
Achromatic objectives are particularly  
suited for specimens with high-contrast  
structures.  
Planachromatic objective 1×  
For the highest requirements for overall image  
quality, we recommend equipping the micro-  
scope with the 1× plan (flat-field) objective,  
which returns sharp, contrast-rich object fields  
all the way to the border.  
Flat-field (planachromatic) objectives are  
particularly well suited for studying flat  
objects such as wafers and thin sections.  
With planapochromatic objectives, the  
finest structures are visible with high  
contrast. The sophisticated apochromatic  
correction allows these objectives to attain  
the highest color brilliance and fidelity.  
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Leica M series  
46  
Bases  
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Leica M series  
47  
Leica TL5000 Ergo Transmitted Light Base: Controls  
2
1
1
2
4 5  
1
3
2
Rear side of the TL5000 Ergo  
Left side of the TL5000 Ergo  
Right side of the TL5000 Ergo  
1
2
Power switch for the base  
Power supply connection  
1
2
3
LED display for opening and positioning  
the aperture or for balance in DF mode.  
Control for the size of the aperture/  
balance  
"BF" button for bright field (press and  
hold for 2 seconds to (de)activate the  
automatic aperture)  
1
2
On/Off switch for the light source / Press and  
hold for 5 seconds to reset the base to factory  
default settings  
Controls for controlling the brightness inten-  
sity  
4
5
"RC" button for Rottermann Contrast / in  
the RC mode, press and hold the button  
to define the aperture size  
"DF" button for dark field  
Refer also to the separately provided  
User Manual for the TL5000 Ergo trans-  
mitted light base.  
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Leica M series  
48  
Leica TL5000 Ergo Transmitted Light Base: Operation  
The transmitted light base must only be  
connected to a grounded socket with a  
faultless power cable! Failure to observe these  
warnings may result in serious personal injury  
or even death!  
Switching the transmitted light base on  
and off  
1. Switch on the transmitted light base with  
the power switch on the rear side.  
2. Press the on/off switch on the right side  
once to turn on the illumination.  
The LED illumination can be very bright!  
Check and adjust the intensity of the  
illumination to a suitable brightness before  
looking through the eyepieces.  
Continued on next page.  
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Leica M series  
49  
Leica TL5000 Ergo Transmitted Light Base: Operation (Continued)  
3. Look through the eyepiece and adjust the  
light intensity using the control on the  
right side. The intensity of the illumination  
is visualized by the LED scale.  
The following assumes that the power  
switch on the rear side of the device  
is always switched on. This switch is not  
mentioned in the remaining part of this User  
Manual.  
4
Press the on/off switch on the right side  
once again to turn off the illumination on  
the base.  
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Leica M series  
50  
Technical Data  
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Leica M series  
51  
Leica TL5000 Ergo Transmitted Light Base  
Light source  
Light source  
LED  
Illuminated field: Bright field ∅  
Illuminated field: Dark field ∅  
Relief Contrast System (RC™)  
Internal shutter/lamp control  
Integrated filter holder  
Matching of high num. aperture  
Remote control options  
AntiShock™ Pads  
65 mm  
40 mm  
Yes  
Yes  
Yes  
Yes  
Yes  
Yes  
Dimensions (W×H×D)  
Power supply  
412×341×46 mm  
Input  
100–240 VAC 47 – 63 Hz 3.2 A  
33 VDC 3.93 A 130 W MAX  
Output  
Connections  
Power supply  
1
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User Manual  
52  
Appendix  
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Leica M series  
53  
Calculating the Total Magnification and Field of View Diameter  
Parameter  
Example  
MO  
ME  
z
Magnification of objective  
MO  
ME  
z
1× objective  
Magnification of eyepiece  
25×/9.5 eyepiece  
Magnification changer position  
Zoom position 4  
q
Tube factor, e.g. 1.5× for coaxial incident light, 1.6× for 45°  
ErgoTube™  
q
Coaxial incident light 1.5×, tube factor  
Factor 1.25×  
r
r
Factor 1.25× if the planachromatic and planapochromatic  
objectives of the MZ125/MZ16 are used on the MS5, MZ6,  
MZ75 or MZ95  
NFOV Field number of the eyepiece. Field numbers are printed on the  
eyepieces: 10× = 21, 16× = 14, 25× = 9.5, 40× = 6.  
Calculation example: magnification in the binocular tube  
Calculation example: field of view diameter in the specimen  
MTOT VIS = MO × ME × z × q × r  
or  
1 × 25 × 4 × 1.5 × 1.25 = 187.5×  
N
FOV  
OF:  
M
O × z ×q ×r  
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Leica M series  
54  
 
Care, Maintenance, Contact Persons  
We hope you enjoy using your high-perfor-  
mance microscope. Leica microscopes are  
renowned for their robustness and long service  
life. Observing the following care and clean-  
ing tips will ensure that even after years and  
decades, your Leica microscope will continue to  
work as well as it did on the very first day.  
EC Declaration of Conformity  
To download the EC Declaration of Conformity,  
use this link  
Care  
Protect your microscope from moisture,  
fumes and acids and from alkaline, caustic  
and corrosive materials and keep chemicals  
away from the instruments.  
products/stereo-microscopes-macroscopes/  
research-manual/  
Plugs, optical systems and mechanical parts  
must not be disassembled or replaced,  
unless doing so is specifically permitted  
and described in this manual.  
Warranty benefits  
Select the microscope type and go to the  
"Download" page.  
The guarantee covers all faults in materials  
and manufacture. It does not, however, cover  
damage resulting from careless or improper  
handling.  
Protect your microscope from oil and  
grease.  
Do not grease guide surfaces or mechani-  
cal parts.  
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Leica M series  
55  
 
Care, Maintenance, Contact Persons (continued)  
Protection from dirt  
Cleaning polymer components  
Permitted measures  
Dust and dirt will affect the quality of your  
results.  
Some components are made of polymer or are  
polymer-coated. They are, therefore, pleasant  
and convenient to handle. The use of unsuit-  
able cleaning agents and techniques can  
damage polymers.  
Clean the microscope (or parts of it)  
using warm soapy water, then wipe using  
distilled water.  
Put a dust cover over the microscope when  
it will not be used for a long time.  
For stubborn dirt, you can also use ethanol  
(industrial alcohol) or isopropanol. When  
doing so, follow the corresponding safety  
regulations.  
Use dust caps to protect tube openings,  
tubes without eyepieces, and eyepieces.  
Keep accessories in a dust-free place when  
not in use.  
Remove dust with a bellows and a soft  
paintbrush.  
Clean eyepieces and objectives with special  
optics cleaning cloths and pure alcohol.  
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Leica M series  
56  
 
Copyright © Leica Microsystems CMS GmbH • Ernst-Leitz-Straße • 35578 Wetzlar  
Germany 2013 • Phone +49 6441-29-0 • Fax +49 6441-29-2599  
LEICA and the Leica logos are registered trademarks of Leica IR GmbH.  
Printed on chlorine-free bleached paper. III/13/M.H. Revision 1.0, issued March 14th, 2013  
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